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Home - Products - Chromatin/Epigenetic - Histone Demethylase - L-α-Hydroxyglutaric acid disodium salt

L-α-Hydroxyglutaric acid disodium salt

CAS No. 63512-50-5

L-α-Hydroxyglutaric acid disodium salt( L-2-Hydroxyglutarate | L-2-HG )

Catalog No. M15402 CAS No. 63512-50-5

L-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutarate;L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    L-α-Hydroxyglutaric acid disodium salt
  • Note
    Research use only, not for human use.
  • Brief Description
    L-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutarate;L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases.
  • Description
    L-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutarate;L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 0.628 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
  • In Vitro
    L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes.
  • In Vivo
    ——
  • Synonyms
    L-2-Hydroxyglutarate | L-2-HG
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Histone Demethylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    63512-50-5
  • Formula Weight
    194.1
  • Molecular Formula
    C5H6Na2O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 83.33 mg/mL (433.83 mM)
  • SMILES
    C(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+]
  • Chemical Name
    Pentanedioic acid, 2-hydroxy-, disodium salt, (S)- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30. 2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
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